Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans.
Identifieur interne : 000041 ( Main/Exploration ); précédent : 000040; suivant : 000042Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans.
Auteurs : Mary L. Mckee [Irlande (pays)] ; Limian Zheng [Irlande (pays)] ; Elaine C. O'Sullivan [Irlande (pays)] ; Roberta A. Kehoe [Irlande (pays)] ; Barbara M. Doyle Prestwich [Irlande (pays)] ; John J. Mackrill [Irlande (pays)] ; Florence O. Mccarthy [Irlande (pays)]Source :
- Pathogens (Basel, Switzerland) [ 2076-0817 ] ; 2020.
Abstract
The pathogen Phytophthora infestans is responsible for worldwide catastrophic crop damage and discovery of new inhibitors of this organism is of paramount agricultural and industrial importance. Current strategies for crop treatment are inadequate with limitations of efficacy and market alternatives. Ellipticines have recently been reported to have fungicidal properties and have been assessed against P. infestans growth with promising results. We hereby report a probe of the ellipticine framework to investigate the alkyl subunit and screen a set ellipticines and derivatives to identify new lead compounds to act against P. infestans. A series of ellipticinium salt derivatives have been identified with exceptional growth inhibitory activity and apparent lack of toxicity towards a human cell-line surpassing the effect of known and marketed fungicides. This report identifies the potential of this natural product derivative as a novel fungicide.
DOI: 10.3390/pathogens9070558
PubMed: 32664299
PubMed Central: PMC7400634
Affiliations:
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Mccarthy</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, Cork T12 K8AF, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, Cork T12 K8AF</wicri:regionArea><wicri:noRegion>Cork T12 K8AF</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pathogens (Basel, Switzerland)</title><idno type="ISSN">2076-0817</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathogen <i>Phytophthora infestans</i> is responsible for worldwide catastrophic crop damage and discovery of new inhibitors of this organism is of paramount agricultural and industrial importance. Current strategies for crop treatment are inadequate with limitations of efficacy and market alternatives. Ellipticines have recently been reported to have fungicidal properties and have been assessed against <i>P. infestans</i> growth with promising results. We hereby report a probe of the ellipticine framework to investigate the alkyl subunit and screen a set ellipticines and derivatives to identify new lead compounds to act against <i>P. infestans</i>. A series of ellipticinium salt derivatives have been identified with exceptional growth inhibitory activity and apparent lack of toxicity towards a human cell-line surpassing the effect of known and marketed fungicides. This report identifies the potential of this natural product derivative as a novel fungicide.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32664299</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2076-0817</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>10</Day></PubDate></JournalIssue><Title>Pathogens (Basel, Switzerland)</Title><ISOAbbreviation>Pathogens</ISOAbbreviation></Journal><ArticleTitle>Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of <i>Phytophthora infestans</i>.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E558</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/pathogens9070558</ELocationID><Abstract><AbstractText>The pathogen <i>Phytophthora infestans</i> is responsible for worldwide catastrophic crop damage and discovery of new inhibitors of this organism is of paramount agricultural and industrial importance. Current strategies for crop treatment are inadequate with limitations of efficacy and market alternatives. Ellipticines have recently been reported to have fungicidal properties and have been assessed against <i>P. infestans</i> growth with promising results. We hereby report a probe of the ellipticine framework to investigate the alkyl subunit and screen a set ellipticines and derivatives to identify new lead compounds to act against <i>P. infestans</i>. A series of ellipticinium salt derivatives have been identified with exceptional growth inhibitory activity and apparent lack of toxicity towards a human cell-line surpassing the effect of known and marketed fungicides. This report identifies the potential of this natural product derivative as a novel fungicide.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McKee</LastName><ForeName>Mary L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, Cork T12 K8AF, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Limian</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Physiology, School of Medicine, University College Cork, Western Road, Cork T12 K8AF, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Sullivan</LastName><ForeName>Elaine C</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, Cork T12 K8AF, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kehoe</LastName><ForeName>Roberta A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, Cork T12 K8AF, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doyle Prestwich</LastName><ForeName>Barbara M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>School of Biological, Earth and Environmental Sciences, University College Cork, Western Road, Cork T12 K8AF, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mackrill</LastName><ForeName>John J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Physiology, School of Medicine, University College Cork, Western Road, Cork T12 K8AF, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Florence O</ForeName><Initials>FO</Initials><AffiliationInfo><Affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, Cork T12 K8AF, Ireland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>15S669</GrantID><Agency>Department of Agriculture, Food and the Marine, Ireland</Agency><Country></Country></Grant><Grant><GrantID>Elaine O'Sullivan and Mary McKee</GrantID><Agency>Irish Research Council</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Pathogens</MedlineTA><NlmUniqueID>101596317</NlmUniqueID><ISSNLinking>2076-0817</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Phytophthora infestans</Keyword><Keyword MajorTopicYN="N">ellipticinium salts</Keyword><Keyword MajorTopicYN="N">isoellipticines</Keyword><Keyword MajorTopicYN="N">mycelial growth</Keyword><Keyword MajorTopicYN="N">oomycete</Keyword><Keyword MajorTopicYN="N">zoosporogenesis</Keyword></KeywordList><CoiStatement>The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>02</Day></PubMedPubDate><PubMedPubDate 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Mckee</name></noRegion><name sortKey="Doyle Prestwich, Barbara M" sort="Doyle Prestwich, Barbara M" uniqKey="Doyle Prestwich B" first="Barbara M" last="Doyle Prestwich">Barbara M. Doyle Prestwich</name><name sortKey="Kehoe, Roberta A" sort="Kehoe, Roberta A" uniqKey="Kehoe R" first="Roberta A" last="Kehoe">Roberta A. Kehoe</name><name sortKey="Mackrill, John J" sort="Mackrill, John J" uniqKey="Mackrill J" first="John J" last="Mackrill">John J. Mackrill</name><name sortKey="Mccarthy, Florence O" sort="Mccarthy, Florence O" uniqKey="Mccarthy F" first="Florence O" last="Mccarthy">Florence O. Mccarthy</name><name sortKey="O Sullivan, Elaine C" sort="O Sullivan, Elaine C" uniqKey="O Sullivan E" first="Elaine C" last="O'Sullivan">Elaine C. O'Sullivan</name><name sortKey="Zheng, Limian" sort="Zheng, Limian" uniqKey="Zheng L" first="Limian" last="Zheng">Limian Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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